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Café Caco Restaurant, Ottawa | OttawaRestos
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Anthocyanin Absorption and Metabolism by Human Intestinal Caco ...
One of the key factors affecting the bioavailability of anthocyanins is their transport through the gut epithelium.
The Caco-2 cell line, a human intestinal epithelial cell model derived from a colon carcinoma, has been proven to be a good alternative to animal studies for predicting intestinal absorption of anthocyanins.
Studies investigating anthocyanin absorption by Caco-2 cells report very low absorption of these compounds.
However, the bioavailability of anthocyanins may be underestimated since the metabolites formed in the course of digestion could be responsible for the health benefits associated with anthocyanins.
In this review, we critically discuss recent findings reported on the anthocyanin absorption and metabolism by human intestinal Caco-2 cells.
Phys. Rev. Lett. 119, 147201 (2017) - Effective One-Dimensional ...
(a),(c) LO and (b),(d) TR cuts of data through (0.55, 0.55) at (a),(b) 52.5–57.5 and (c),(d) 42.5–47.5 meV.
TR cuts were averaged from 0.3–0.8 r.l.u. in the LO direction and LO cuts in the TR directions.
Both data are corrected for the magnetic form factor after subtracting a background contribution estimated from Gaussian fits to the TR cuts.
The green lines in the TR cuts are fits to a Gaussian line shape and blue solid lines are fits to the diffusive model.
(e) Energy dependence of the imaginary part of the dynamical susceptibility centered at (0.55, 0.55) and averaged along the LO direction from 0.3–0.8 r.l.u. Each data point is obtained after fitting the TR cuts with a Gaussian line shape.
Role of Caco-2 cell monolayers in prediction of intestinal drug ...
The usefulness of Caco-2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review.
The role of Caco-2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.
The Caco-2 cell monolayer: usefulness and limitations.
The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp).
Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic enzymes that are sandwiched between two membrane barriers with distinctly different transporters.
This review addressed the usefulness and limitations of the Caco-2 cell monolayer in drug discovery and mechanistic studies.
This mini-review covered applications of the Caco-2 monolayer, clarified misconceptions, and critically addressed issues on data interpretation.
The catenary model extends the usefulness of Caco-2 monolayer and provides proper mechanistic insight and data interpretation.
Anthocyanin Absorption and Metabolism by Human Intestinal Caco ...
One of the key factors affecting the bioavailability of anthocyanins is their transport through the gut epithelium.
The Caco-2 cell line, a human intestinal epithelial cell model derived from a colon carcinoma, has been proven to be a good alternative to animal studies for predicting intestinal absorption of anthocyanins.
Studies investigating anthocyanin absorption by Caco-2 cells report very low absorption of these compounds.
However, the bioavailability of anthocyanins may be underestimated since the metabolites formed in the course of digestion could be responsible for the health benefits associated with anthocyanins.
In this review, we critically discuss recent findings reported on the anthocyanin absorption and metabolism by human intestinal Caco-2 cells.